Work package 4: Training in metabolic & autophagy defects in the dopamine neuron
Coordinated by Juan Bolanos, Universidad de Salamanca
- ESR1 Modulation of antioxidant status in dysfunctional dopaminergic neurons
- ESR2 Characterisation of the redox status inside dopamine neurons using conditional transgenic mouse models
- ESR3 The effect of glutathione on mitochondrial dynamics & function in the dopamine neuron
- ESR4 How does the cytochrome P450 system control drug metabolism in the dopamine neuron?
- ER1 The mechanisms that control mitochondrial dynamics & function in the dopamine neuron
Work package 5: Training in glycoanalytics for neurodegeneration biomarkers
Coordinated by Gavin Davey, Trinity College Dublin.
- ESR5 Crosstalk between mitochondrial & lysosomal dysfunction in the dopamine neuron
- ESR6 How does glucocerebrosidase control autophagy in the dopamine neuron?
- ER2 What mechanisms control autophagy in the dopamine neuron?
Work package 6: Training in innovative models of neurodegeneration
Coordinated by Gavin Davey, Trinity College Dublin.
- ESR7 Human wild type and parkinsonian iPS cell lines
- ESR8 Neurotoxin models of Parkinson's disease & characterisation of the dopamine transporter internalisation process in patient-specific dopamine neurons
Work package 7: Work package 7: Training in computational analysis & drug design
Coordinated by Kemal Yelekci, Kadir Has University.
- ESR9 In-silico reconstruction of the dopamine transporter and design of new drugs with neuroprotective properties
- ESR10 Development of new drugs to inhibit the neurodegenerative process in dopamine neurons
Work package 8: Training in biomarker development and commercialisation
Coordinated by Sabine Flitsch, University of Manchester
